Anti-Hox8/MSX2 Antibody Picoband®

About this product

Boster Bio Anti-Hox8/MSX2 Antibody Picoband® catalog # A01783-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A01783-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene. This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.

Synonyms

Farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E) -farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase; Fdps

Gene Name

MSX2

Gene ID

4488

UniProt

P35548

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Hox8/MSX2 recombinant protein (Position: M1-M129) .

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Immunoglobulins, Immunology, Nuclear Import/Export, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

References & Citations

1. Bernardini, L., Castori, M., Capalbo, A., Mokini, V., Mingarelli, R., Simi, P., Bertuccelli, A., Novelli, A., Dallapiccola, B. Syndromic craniosynostosis due to complex chromosome 5 rearrangement and MSX2 gene triplication. Am. J. Med. Genet. 143A: 2937-2943, 2007. 2. Davidson, D. The function and evolution of Msx genes: pointers and paradoxes. Trends Genet. 11: 405-411, 1995. 3. Florisson, J. M. G., Verkerk, A. J. M. H., Huigh, D., Hoogeboom, A. J. M., Swagemakers, S., Kremer, A., Heijsman, D., Lequin, M. H., Mathijssen, I. M. J., van der Spek, P. J. Boston type craniosynostosis: report of a second mutation in MSX2. Am. J. Med. Genet. 161A: 2626-2633, 2013.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

57862 MW

Observed Molecular Weight

37 kDa

Applications Notes

6

Gene Name Synonym

Farnesyl diphosphate synthetase

Subcellular Location

Cytoplasm.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.