Anti-TIM 4/TIMD4 Antibody Picoband®

About this product

Boster Bio Anti-TIM 4/TIMD4 Antibody Picoband® catalog # A06637-2. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06637-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.

Synonyms

Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; Gp2

Gene Name

TIMD4

Gene ID

91937

UniProt

Q96H15

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TIM 4/TIMD4 recombinant protein (Position: S24-L378) .

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.

Applications

WB, ELISA

Field of Research

Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

References & Citations

1. Czuczman, M. A., Fattouh, R., van Rijn, J. M., Canadien, V., Osborne, S., Muise, A. M., Kuchroo, V. K., Higgins, D. E., Brumell, J. H. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature 509: 230-234, 2014. 2. Kuchroo, V. K., Umetsu, D. T., DeKruyff, R. H., Freeman, G. J. The TIM gene family: emerging roles in immunity and disease. Nature Rev. Immun. 3: 454-462, 2003. 3. Meyers, J. H., Chakravarti, S., Schlesinger, D., Illes, Z., Waldner, H., Umetsu, S. E., Kenny, J., Zheng, X. X., Umetsu, D. T., DeKruyff, R. H., Strom, T. B., Kuchroo, V. K. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nature Immun. 6: 455-464, 2005.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

104553 MW

Observed Molecular Weight

42 kDa

Gene Name Synonym

Glycoprotein 2 (zymogen granule membrane)

Subcellular Location

Cell membrane. GPI-anchor. Secreted.

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.