Anti-Tlr5 Antibody Picoband®

About this product

Boster Bio Anti-Tlr5 Antibody Picoband® catalog # A00462-2. Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00462-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. Predicted to enable interleukin-1 receptor binding activity and signaling receptor activity. Predicted to be involved in several processes, including positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; and positive regulation of toll-like receptor signaling pathway. Predicted to act upstream of or within innate immune response. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; olfactory epithelium; spinal cord; and trunk unsegmented mesenchyme. Human ortholog (s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5) .

Synonyms

Beta-2-microglobulin; B2m

Gene Name

Tlr5

Gene ID

53791

UniProt

Q9JLF7

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse Tlr5 recombinant protein (Position: Q81-D766) .

Clonality

Polyclonal

Tissue Specificity

Detected in lung, spleen, uterus, vagina and epididymis. .

Applications

WB, ELISA

Field of Research

Immunoglobulins, Immunology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Component of the class I major histocompatibility complex (MHC) . Involved in the presentation of peptide antigens to the immune system.

References & Citations

1. Andersen-Nissen, E., Hawn, T. R., Smith, K. D., Nachman, A., Lampano, A. E., Uematsu, S., Akira, S., Aderem, A. Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. J. Immun. 178: 4717-4720, 2007. 2. Andersen-Nissen, E., Smith, K. D., Bonneau, R., Strong, R. K., Aderem, A. A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J. Exp. Med. 204: 393-403, 2007. 3. Burdelya, L. G., Krivokrysenko, V. I., Tallant, T. C., Strom, E., Gleiberman, A. S., Gupta, D., Kurnasov, O. V., Fort, F. L., Osterman, A. L., DiDonato, J. A., Feinstein, E., Gudkov, A. V. An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320: 226-230, 2008.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

22875 MW

Observed Molecular Weight

100 kDa

Gene Name Synonym

Beta-2 microglobulin

Subcellular Location

Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Protein Name

Neutrophil gelatinase-associated lipocalin

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.