Anti-SLC3A1 Antibody Picoband®

About this product

Boster Bio Anti-SLC3A1 Antibody Picoband® catalog # A02654-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02654-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene. This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Synonyms

Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; DPT

Gene Name

SLC3A1

Gene ID

6519

UniProt

Q07837

Host

Rabbit

Reactivity

Human, Monkey, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SLC3A1 recombinant protein (Position: K70-R665) .

Clonality

Polyclonal

Tissue Specificity

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.

Applications

ELISA, Flow Cytometry, WB

Field of Research

Biochemicals, Chemical Type, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity) .

References & Citations

1. Barbosa, M., Lopes, A., Mota, C., Martins, E., Oliveira, J., Alves, S., De Bonis, P., do Ceu Mota, M., Dias, C., Rodrigues-Santos, P., Fortuna, A. M., Quelhas, D., Lacerda, L., Bisceglia, L., Cardoso, M. L. Clinical, biochemical and molecular characterization of cystinuria in a cohort of 12 patients. Clin. Genet. 81: 47-55, 2012. 2. Bartoccioni, P., Rius, M., Zorzano, A., Palacin, M., Chillaron, J. Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype. Hum. Molec. Genet. 17: 1845-1854, 2008. 3. Bisceglia, L., Calonge, M. J., Strologo, L. D., Rizzoni, G., de Sanctis, L., Gallucci, M., Beccia, E., Testar, X., Zorzano, A., Estivill, X., Zelante, L., Palacin, M., Gasparini, P., Nunes, V. Molecular analysis of the cystinuria disease gene: identification of four new mutations, one large deletion, and one polymorphism. Hum. Genet. 98: 447-451, 1996.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

33310 MW

Observed Molecular Weight

110 kDa

Applications Notes

6

Gene Name Synonym

Dermatopontin

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.