Anti-TOX2 Antibody Picoband®

About this product

Boster Bio Anti-TOX2 Antibody Picoband® catalog # A12956-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A12956-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

TOX high mobility group box family member 2, also known as TOX2, is a human gene. Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm.

Synonyms

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283

Gene Name

TOX2

Gene ID

84969

UniProt

Q96NM4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TOX2 recombinant protein (Position: Q41-A425) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Complement, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

References & Citations

1. Kajitani, T., Mizutani, T., Yamada, K., Yazawa, T., Sekiguchi, T., Yoshino, M., Kawata, H., Miyamoto, K. Cloning and characterization of granulosa cell high-mobility group (HMG) -box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Endocrinology 145: 2307-2318, 2004. 2. Scott, A. F. Personal Communication. Baltimore, Md. 7/3/2007.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

70 kDa

Applications Notes

6

Gene Name Synonym

C3 and PZP like, alpha-2-macroglobulin domain containing 8

Subcellular Location

Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.