Anti-TRIM29 Antibody Picoband®

About this product

Boster Bio Anti-TRIM29 Antibody Picoband® catalog # A04472-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04472-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene. The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype

Synonyms

Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A

Gene Name

TRIM29

Gene ID

23650

UniProt

Q14134

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TRIM29 recombinant protein (Position: E169-R549) .

Clonality

Polyclonal

Tissue Specificity

Leukocytes.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

References & Citations

1. Brzoska, P. M., Chen, H., Zhu, Y., Levin, N. A., Disatnik, M.-H., Mochly-Rosen, D., Murnane, J. P., Christman, M. F. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. Proc. Nat. Acad. Sci. 92: 7824-7828, 1995. 2. Dou, Y., Xing, J., Kong, G., Wang, G., Lou, X., Xiao, X., Vivier, E., Li, X. C., Zhang, Z. Identification of the E3 ligase TRIM29 as a critical checkpoint regulator of NK cell functions. J. Immun. 203: 873-880, 2019. 3. Hosoi, Y., Kapp, L. N., Murnane, J. P., Matsumoto, Y., Enomoto, A., Ono, T., Miyagawa, K. Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. Biochem. Biophys. Res. Commun. 348: 728-734, 2006.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

128770 MW

Observed Molecular Weight

70 kDa

Applications Notes

6

Gene Name Synonym

Integrin alpha-L

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Integrin alpha-L

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.