Anti-SARDH Antibody Picoband®

About this product

Boster Bio Anti-SARDH Antibody Picoband® catalog # A09641-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A09641-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sarcosine dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the SARDH gene. This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described.

Synonyms

Band 4.1-like protein 5; EPB41L5; KIAA1548

Gene Name

SARDH

Gene ID

1757

UniProt

Q9UL12

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SARDH recombinant protein (Position: M1-E640) .

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Applications

WB, Flow Cytometry, ELISA

Field of Research

Epigenetics and Nuclear Signaling, Mediator Complex, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.

References & Citations

1. Bar-joseph, I., Pras, E., Reznik-Wolf, H., Marek-Yagel, D., Abu-Horvitz, A., Dushnitzky, M., Goldstein, N., Rienstein, S., Dekel, M., Pode-Shakked, B., Zlotnik, J., Benarrosh, A., Gillery, P., Hofliger, N., Auray-Blais, C., Garnotel, R., Anikster, Y. Mutations in the sarcosine dehydrogenase gene in patients with sarcosinemia. Hum. Genet. 131: 1805-1810, 2012. 2. Brunialti, A. L. B., Harding, C. O., Wolff, J. A., Guenet, J.-L. The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34. Genomics 36: 182-184, 1996. 3. Eschenbrenner, M., Jorns, M. S. Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia. Genomics 59: 300-308, 1999.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

101 kDa

Applications Notes

6

Gene Name Synonym

Erythrocyte membrane protein band 4.1 like 5

Subcellular Location

Cell membrane. Single-pass membrane protein. Postsynaptic cell membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.