Anti-TNNI3K Antibody Picoband®

About this product

Boster Bio Anti-TNNI3K Antibody Picoband® catalog # A06499-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06499-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

TNNI3 interacting kinase is a protein that in humans is encoded by the TNNI3K gene. This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology.

Synonyms

Max dimerization protein 1; Max dimerizer 1; Protein MAD; MXD1; MAD

Gene Name

TNNI3K

Gene ID

51086

UniProt

Q59H18

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TNNI3K recombinant protein (Position: F102-Q783) .

Clonality

Polyclonal

Applications

WB, Flow Cytometry, ELISA

Field of Research

Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.

References & Citations

1. Fan, L.-L., Huang, H., Jin, J.-Y., Li, J.-J., Chen, Y.-Q., Zhao, S.-P., Xiang, R. Whole exome sequencing identifies a novel mutation (c.333+2T-C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease. Gene 648: 63-67, 2018. 2. Lai, Z.-F., Chen, Y.-Z., Feng, L.-P., Meng, X.-M., Ding, J.-F., Wang, L.-Y., Ye, J., Li, P., Cheng, X.-S., Kitamoto, Y., Monzen, K., Komuro, I., Sakaguchi, N., Kim-Mitsuyama, S. Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury. Am. J. Physiol. Heart Circ. Physiol. 295: H708-H716, 2008. Note: Erratum: Am. J. Physiol. Heart Circ. Physiol. 295: H1815 only, 2008. 3. Patterson, M., Barske, L., Van Handel, B., Rau, C. D., Gan, P., Sharma, A., Parikh, S., Denholtz, M., Huang, Y., Yamaguchi, Y., Shen, H., Allayee, H., Crump, J. G., Force, T. I., Lien, C.-L., Makita, T., Lusis, A. J., Kumar, S. R., Sucov, H. M. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nature Genet. 49: 1346-1353, 2017.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

110 kDa

Applications Notes

6

Gene Name Synonym

MAX dimerization protein 1

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.