Anti-TTLL12 Antibody Picoband®

About this product

Boster Bio Anti-TTLL12 Antibody Picoband® catalog # A14589-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A14589-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm.

Synonyms

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

Gene Name

TTLL12

Gene ID

23170

UniProt

Q14166

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TTLL12 recombinant protein (Position: E8-Q634) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

ELISA, Flow Cytometry, IHC, WB

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

References & Citations

1. Brants, J., Semenchenko, K., Wasylyk, C., Robert, A., Carles, A., Zambrano, A., Pradeau-Aubreton, K., Birck, C., Schalken, J. A., Poch, O., de Mey, J., Wasylyk, B. Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS One 7: e51258, 2012. 2. Gross, M. B. Personal Communication. Baltimore, Md. 6/28/2021. 3. Ju, L.-G., Zhu, Y., Lei, P.-J., Yan, D., Zhu, K., Wang, X., Li, Q.-L., Li, X.-J., Chen, J.-W., Li, L.-Y., Wu, M. TTLL12 inhibits the activation of cellular antiviral signaling through interaction with VISA/MAVS. J. Immun. 198: 1274-1284, 2017.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

64099 MW

Observed Molecular Weight

75 kDa

Applications Notes

6

Gene Name Synonym

DAP3 binding cell death enhancer 1

Subcellular Location

Mitochondrion.

Protein Name

DAP3 binding cell death enhancer 1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.