Anti-Thymidylate Synthase/TYMS Antibody Picoband®

About this product

Boster Bio Anti-Thymidylate Synthase/TYMS Antibody Picoband® catalog # A04320-4. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Monkey, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A04320-4

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

Synonyms

Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD123; IL3RA; IL3R

Gene Name

TYMS

Gene ID

7298

UniProt

P04818

Host

Rabbit

Reactivity

Human, Monkey, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Thymidylate Synthase/TYMS recombinant protein (Position: M1-V313) .

Clonality

Polyclonal

Tissue Specificity

Brain.

Applications

ELISA, IF, IHC, WB

Field of Research

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

This is a receptor for interleukin-3.

References & Citations

1. Chu, J., Dolnick, B. J. Natural antisense (rTS-alpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. Biochim. Biophys. Acta 1587: 183-193, 2002. 2. Hori, T., Ayusawa, D., Shimizu, K., Koyama, H., Seno, T. Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-negative mouse mutant cells and human diploid fibroblasts. Somat. Cell Molec. Genet. 11: 277-283, 1985. 3. Hori, T., Ayusawa, D., Shimizu, K., Koyama, H., Seno, T. Assignment of the human TMS gene, encoding thymidylate synthase, to chromosome 18. (Abstract) Cytogenet. Cell Genet. 40: 654-655, 1985.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

36 kDa

Gene Name Synonym

Interleukin 3 receptor subunit alpha

Subcellular Location

Membrane. Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.