Anti-SLC20A1 Antibody Picoband®

About this product

Boster Bio Anti-SLC20A1 Antibody Picoband® catalog # A03537-1. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A03537-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene. The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.

Synonyms

Segment polarity protein dishevelled homolog DVL-1; Dishevelled-1; DSH homolog 1; DVL1

Gene Name

SLC20A1

Gene ID

6574

UniProt

Q8WUM9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human SLC20A1 recombinant protein (Position: A79-K494) .

Clonality

Polyclonal

Tissue Specificity

Found in embryos and in adult liver and heart.

Applications

ELISA, IF, IHC, WB

Field of Research

Cytoplasmic, Signaling Pathways, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) .

References & Citations

1. Beck, L., Leroy, C., Beck-Cormier, S., Forand, A., Salaun, C., Paris, N., Bernier, A., Urena-Torres, P., Prie, D., Ollero, M., Coulombel, L., Friedlander, G. The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PLoS One 5: e9148, 2010. 2. Inden, M., Iriyama, M., Zennami, M., Sekine, S., Hara, A., Yamada, M., Hozumi, I. The type III transporters (PiT-1 and PiT-2) are the major sodium-dependent phosphate transporters in the mice and human brains. Brain Res. 1637: 128-136, 2016. 3. Kaelbling, M., Eddy, R., Shows, T. B., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Klinger, H. P., O'Hara, B. Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2. J. Virol. 65: 1743-1747, 1991.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

75187 MW

Observed Molecular Weight

85 kDa

Gene Name Synonym

Segment polarity protein dishevelled homolog DVL-1

Subcellular Location

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members. .

Protein Name

Segment polarity protein dishevelled homolog DVL-1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.