Anti-OPLAH Antibody Picoband®

About this product

Boster Bio Anti-OPLAH Antibody Picoband® catalog # A11695-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A11695-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD) .

Synonyms

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

Gene Name

OPLAH

Gene ID

26873

UniProt

O14841

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human OPLAH recombinant protein (Position: H788-E1072) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

References & Citations

1. Almaghlouth, I. A., Mohamed, J. Y., Al-Amoudi, M., Al-Ahaidib, L., Al-Odaib, A., Alkuraya, F. S. 5-Oxoprolinase deficiency: report of the first human OPLAH mutation. Clin. Genet. 82: 193-196, 2012. 2. Calpena, E., Casado, M., Martinez-Rubio, D., Nascimento, A., Colomer, J., Gargallo, E., Garcia-Cazorla, A., Palau, F., Artuch, R., Espinos, C. 5-Oxoprolinuria in heterozygous patients for 5-oxoprolinase (OPLAH) missense changes. JIMD Rep. 7: 123-128, 2013. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 9/22/2011.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

140 kDa

Applications Notes

6

Gene Name Synonym

Eva-1 homolog A, regulator of programmed cell death

Subcellular Location

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.