Anti-C19orf61/SMG9 Antibody Picoband®

About this product

Boster Bio Anti-C19orf61/SMG9 Antibody Picoband® catalog # A10233-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A10233-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a regulatory subunit of the SMG1 complex, which plays a critical role in nonsense-mediated mRNA decay (NMD) . Binding of the encoded protein to the SMG1 complex kinase scaffold protein results in the inhibition of its kinase activity. Mutations in this gene cause a multiple congenital anomaly syndrome in human patients, characterized by brain malformation, congenital heart disease and other features.

Synonyms

Protein NDRG3; N-myc downstream-regulated gene 3 protein; NDRG3

Gene Name

SMG9

Gene ID

56006

UniProt

Q9H0W8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human C19orf61/SMG9 recombinant protein (Position: R39-A520) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highly expressed in brain. .

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

References & Citations

1. Lecoquierre, F., Bonnevalle, A., Chadie, A., Gayet, C., Dumant-Forest, C., Renaux-Petel, M., Leca, J. B., Hazelzet, T., Brasseur-Daudruy, M., Louillet, F., Muraine, M., Coutant, S., Quenez, O., Boland, A., Deleuze, J. F., Frebourg, T., Goldenberg, A., Saugier-Veber, P., Guerrot, A. M., Nicolas, G. Confirmation and further delineation of the SMG9-deficiency syndrome, a rare and severe developmental disorder. Am. J. Med. Genet. 179A: 2257-2262, 2019. 2. Rahikkala, E., Urpa, L., Ghimire, B., Topa, H., Kurki, M. I., Koskela, M., Airavaara, M., Hamalainen, E., Pylkas, K., Korkko, J., Savolainen, H., Suoranta, A., Bertoli-Avella, A., Rolfs, A., Mattila, P., Daly, M., Palotie, A., Pietilainen, O., Moilanen, J., Kuismin, O. A novel variant in SMG9 causes intellectual disability, confirming a role for nonsense-mediated decay components in neurocognitive development. Europ. J. Hum. Genet. 30: 619-627, 2022. 3. Shaheen, R., Anazi, S., Ben-Omran, T., Seidahmed, M. Z., Caddle, L. B., Palmer, K., Ali, R., Alshidi, T., Hagos, S., Goodwin, L., Hashem, M., Wakil, S. M., Abouelhoda, M., Colak, D., Murray, S. A., Alkuraya, F. S. Mutations in SMG9, encoding an essential component of nonsense-mediated decay machinery, cause a multiple congenital anomaly syndrome in humans and mice. Am. J. Hum. Genet. 98: 643-652, 2016.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

41409 MW

Observed Molecular Weight

58 kDa

Applications Notes

6

Gene Name Synonym

Protein NDRG3

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

Protein NDRG3

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.