Anti-PLET1 Antibody Picoband®

About this product

Boster Bio Anti-PLET1 Antibody Picoband® catalog # A14923-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A14923-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

PLET-1 (placenta -expressed transcript 1), also known as antigen mAgK114, is a 23 kDa membrane protein that is probably GPI-anchored. It is recognized by the antibodies MTS20 and MTS24. Mature mouse PLET-1, which most likely includes amino acids (aa) 28-216 of 237 aa, shares less than 60% aa sequence identity with the most closely related rat or human protein. A potential 194 aa mouse splice variant diverges after aa 149 but still contains a hydrophobic sequence at the Cterminus. PLET-1 is a marker of early thymic progenitor cells and pancreatic duct epithelium.

Synonyms

Transmembrane protein 240; TMEM240; C1orf70

Gene Name

PLET1

Gene ID

349633

UniProt

Q6UQ28

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PLET1 recombinant protein (Position: D46-K166) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

ELISA, Flow Cytometry, WB

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Depreter, M. G. L., Blair, N. F., Gaskell, T. L., Nowell, C. S., Davern, K., Pagliocca, A., Stenhouse, F. H., Farley, A. M., Fraser, A., Vrana, J., Robertson, K., Morahan, G., Tomlinson, S. R., Blackburn, C. C. Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. Proc. Nat. Acad. Sci. 105: 961-966, 2008. 2. Zhao, S.-H., Simmons, D. G., Cross, J. C., Scheetz, T. E., Casavant, T. L., Soares, M. B., Tuggle, C. K. PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. Genomics 84: 114-125, 2004.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

19908 MW

Observed Molecular Weight

28 kDa

Applications Notes

6

Gene Name Synonym

Transmembrane protein 240

Subcellular Location

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.