Anti-MAD2L2 Antibody Picoband®

About this product

Boster Bio Anti-MAD2L2 Antibody Picoband® catalog # A02357-4. Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A02357-4

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene. The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

Synonyms

Calcitonin; Calca; Calc

Gene Name

MAD2L2

Gene ID

10459

UniProt

Q9UI95

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MAD2L2 recombinant protein (Position: M1-K209) .

Clonality

Polyclonal

Applications

ELISA, IF, IHC, ICC, WB, Flow Cytometry

Field of Research

Cardiovascular, Contractility, Neuropeptides, Neuroscience, Neurotransmitter, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

References & Citations

1. Bluteau, D., Masliah-Planchon, J., Clairmont, C., Rousseau, A., Ceccaldi, R., Dubois d'Enghien, C., Bluteau, O., Cuccuini, W., Gachet, S., Peffault de Latour, R., Leblanc, T., Socie, G., Baruchel, A., Stoppa-Lyonnet, D., D'Andrea, A. D., Soulier, J. Biallelic inactivation of REV7 is associated with Fanconi anemia. J. Clin. Invest. 126: 3580-3584, 2016. Note: Erratum: J. Clin. Invest. 127: 1117 only, 2017. 2. Boersma, V., Moatti, N., Segura-Bayona, S., Peuscher, M. H., van der Torre, J., Wevers, B. A., Orthwein, A., Durocher, D., Jacobs, J. J. L. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5-prime end resection. Nature 521: 537-540, 2015. 3. Cahill, D. P., da Costa, L. T., Carson-Walter, E. B., Kinzler, K. W., Vogelstein, B., Lengauer, C. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics 58: 181-187, 1999.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

24 kDa

Applications Notes

6

Gene Name Synonym

Calcitonin/calcitonin-related polypeptide, alpha

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.