Anti-PACSIN1 Antibody Picoband®

About this product

Boster Bio Anti-PACSIN1 Antibody Picoband® catalog # A06469-1. Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A06188-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Protein kinase C and casein kinase substrate in neurons protein 1 is an enzyme that in humans is encoded by the PACSIN1 gene. PACSIN1 was originally identified as a molecular link between membrane trafficking and actin organization. PACSIN1 interacts with vesicle-associated proteins and plays a role in endocytosis and endosomal recycling. In addition, it has a role in actin remodeling and microtubule nucleation.

Synonyms

70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70 (S6K) alpha antibody, p70 (S6K) -alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody

Gene Name

PACSIN1

Gene ID

29993

UniProt

Q9BY11

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross reactivity with other proteins.

Immunogen

E.coli-derived human PACSIN1 recombinant protein (Position: Q76-E359) . Human PACSIN1 shares 95.8% and 96.5% amino acid (aa) sequence identity with mouse and rat PACSIN1, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues.

Applications

WB, IHC, ICC, IF, Flow Cytometry, ELISA

Field of Research

Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

References & Citations

1. Liu, Y., Lv, K., Li, Z., Yu, A. C. H., Chen, J., Teng, J. PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J. Biol. Chem. 287: 39911-39924, 2012 2. Modregger, J., DiProspero, N.A., Charles, V., Tagle, D.A., Plomann, M. PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains. Hum. Molec. Genet. 11: 2547-2558, 2002. 3. Nagase, T., Kikuno, R., Ishikawa, K., Hirosawa, M., Ohara, O. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 65-73, 2000.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

52588 MW

Observed Molecular Weight

51 kDa

Applications Notes

6

Gene Name Synonym

Serine/threonine-protein kinase AtPK1/AtPK6

Subcellular Location

Cytoplasm. Nucleus.

Protein Name

Serine/threonine-protein kinase AtPK1/AtPK6

Isotype

IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.