Anti-ACE2 Antibody Picoband®

About this product

Boster Bio Anti-ACE2 Antibody Picoband® catalog # A00756-3. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00756-3

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19) . Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.

Gene Name

ACE2

Gene ID

59272

UniProt

Q9BYF1

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived human ACE2 recombinant protein (Position: Q18-F314) . Human ACE2 shares 80.5% and 80.8% amino acid (aa) sequence identity with mouse and rat ACE2, respectively.

Clonality

Polyclonal

Applications

WB, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Boehm, M., Nabel, E. G. Angiotensin-converting enzyme 2--a new cardiac regulator. New Eng. J. Med. 347: 1795-1797, 2002. 2. Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, C. M., Manoukian, A. S., Chappell, M. C., Backx, P. H., Yagil, Y., Penninger, J. M. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417: 822-828, 2002. 3. Gurley, S. B., Allred, A., Le, T. H., Griffiths, R., Mao, L., Philip, N., Haystead, T. A., Donoghue, M., Breitbart, R. E., Acton, S. L., Rockman, H. A., Coffman, T. M. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J. Clin. Invest. 116: 2218-2225, 2006.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

120 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.