Anti-SCARA5 Antibody Picoband®

About this product

Boster Bio Anti-SCARA5 Antibody Picoband® catalog # A09571-2. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A09571-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Scavenger receptor A5 (SCARA5) is also known as testis expressed scavenger receptor (Tesr) . Class A scavenger receptors, including CL-P1, MARCO, SCARA3, and SR-A1, are type II transmembrane proteins that contain a collagenous stalk. Mature human SCARA5 consists of a 60 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 414 aa extracellular domain (ECD) with a spacer, a collagen-like, and a scavenger receptor cysteine-rich (SRCR) domain. Within the ECD, human SCARA5 shares 87% aa sequence identity with mouse and rat SCARA5. It shares 23%?34% aa sequence identity with CL-P1, MARCO, SCARA3, and SR-A1. Alternate splicing generates isoforms that lack the SRCR domain, the transmembrane segment, or the 225 aa spacer region between the membrane and the collagen-like domain. SCARA5 is a cell surface disulfide-linked homotrimer of > 250 kDa. It is highly expressed in testicular Sertoli and germ cells and more weakly in the epithelia of other tissues. During mouse development, SCARA5 expression is attenuated in female embryos at the time of sex determination, whereas it is maintained in the developing testis. SCARA5 is re-expressed in the adult ovary. SCARA5 binds heat-killed bacterial particles but not yeast particles or modified LDL.

Gene Name

SCARA5

Gene ID

286133

UniProt

Q6ZMJ2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human SCARA5 recombinant protein (Position: K31-R288) . Human SCARA5 shares 89.9% amino acid (aa) sequence identity with mouse SCARA5.

Clonality

Polyclonal

Applications

WB, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Huang, J., Zheng, D.-L., Qin, F.-S., Cheng, N., Chen, H., Wan, B.-B., Wang, Y.-P., Xiao, H.-S., Han, Z.-G. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J. Clin. Invest. 120: 223-241, 2010. 2. Jiang, Y., Oliver, P., Davies, K. E., Platt, N. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J. Biol. Chem. 281: 11834-11845, 2006.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Observed Molecular Weight

50 kDa

Isotype

IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.