Anti-ITM2C Antibody Picoband®

About this product

Boster Bio Anti-ITM2C Antibody Picoband® catalog # A08857-1. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A08857-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE) 1 and the microtubule-destabilizing protein SCG10 (STMN2) . It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

Gene Name

ITM2C

Gene ID

81618

UniProt

Q9NQX7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human ITM2C recombinant protein (Position: E33-D226) . Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse and rat ITM2C.

Clonality

Polyclonal

Applications

WB, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Vidal, R., Calero, M., Revesz, T., Plant, G., Ghiso, J., Frangione, B. Sequence, genomic structure and tissue expression of human BRI (3), a member of the BRI gene family. Gene 266: 95-102, 2001. 2. Wickham, L., Benjannet, S., Marcinkiewicz, E., Chretien, M., Seidah, N. G. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI (3) : binding partners processed by furin. J. Neurochem. 92: 93-102, 2005.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

30 kDa

Observed Molecular Weight

35 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.