Anti-PYHIN1 Antibody Picoband®

About this product

Boster Bio Anti-PYHIN1 Antibody Picoband® catalog # A10377-1. Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A10377-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name

PYHIN1

Gene ID

149628

UniProt

Q6K0P9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human PYHIN1 recombinant protein (Position: K86-H488) . Human PYHIN1 shares 45.6% amino acid (aa) sequence identity with mouse PYHIN1.

Clonality

Polyclonal

Applications

WB, IHC, ICC, IF, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Ding, Y., Lee, J.-F., Lu, H., Lee, M.-H., Yan, D.-H. Interferon-inducible protein IFIX-alpha-1 functions as a negative regulator of HDM2. Molec. Cell. Biol. 26: 1979-1996, 2006. 2. Ding, Y., Wang, L., Su, L.-K., Frey, J. A., Shao, R., Hunt, K. K., Yan, D.-H. Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene 23: 4556-4566, 2004. 3. Yamaguchi, H., Ding, Y., Lee, J.-F., Zhang, M., Pal, A., Bornmann, W., Yan, D.-H., Hung, M.-C. Interferon-inducible protein IFIX-alpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Molec. Carcinogen. 47: 739-743, 2008.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

55 kDa

Observed Molecular Weight

55 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.