Anti-TBR1 Antibody Picoband®

About this product

Boster Bio Anti-TBR1 Antibody Picoband® catalog # A07503-2. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A07503-2

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.

Gene Name

TBR1

Gene ID

10716

UniProt

Q16650

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

E.coli-derived human TBR1 recombinant protein (Position: K15-S682) . Human TBR1 shares 99.3% amino acid (aa) sequence identity with mouse TBR1.

Clonality

Polyclonal

Applications

WB, IHC, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Bulfone, A., Smiga, S. M., Shimamura, K., Peterson, A., Puelles, L., Rubenstein, J. L. R. T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron 15: 63-78, 1995. 2. den Hoed, J., Sollis, E., Venselaar, H., Estruch, S. B., Deriziotis, P., Fisher, S. E. Functional characterization of TBR1 variants in neurodevelopmental disorder. Sci. Rep. 8: 14279, 2018. 3. Deriziotis, P., O'Roak, B. J., Graham, S. A., Estruch, S. B., Dimitropoulou, D., Bernier, R. A., Gerdts, J., Shendure, J., Eichler, E. E., Fisher, S. E. De novo TBR1 mutations in sporadic autism disrupt protein functions. Nature Commun. 5: 4954, 2014. Note: Electronic Article.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

74 kDa

Observed Molecular Weight

74 kDa

Applications Notes

6

Isotype

IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.