Anti-NAGLU Antibody Picoband®

About this product

Boster Bio Anti-NAGLU Antibody Picoband® catalog # A03549. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A03549-carrier-free

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

N-acetylglucosaminidase, alpha is a protein that in humans is encoded by the NAGLU gene. This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate.

Synonyms

NAGLU; UFHSD1; Alpha-N-acetylglucosaminidase; EC 3.2.1.50; N-acetyl-alpha-glucosaminidase; NAG [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]

Gene Name

NAGLU

Gene ID

4669

UniProt

P54802

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human NAGLU recombinant protein (Position: D24-D489) .

Clonality

Polyclonal

Applications

WB, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Beesley, C. E., Young, E. P., Vellodi, A., Winchester, B. G. Identification of 12 novel mutations in the alpha-N-acetylglucosaminidase gene in 14 patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB) . J. Med. Genet. 35: 910-914, 1998. 2. Bunge, S., Knigge, A., Steglich, C., Kleijer, W. J., van Diggelen, O. P., Beck, M., Gal, A. Mucopolysaccharidosis type IIIB (Sanfilippo B) : identification of 18 novel alpha-N-acetylglucosaminidase gene mutations. J. Med. Genet. 36: 28-31, 1999. 3. Chinen, Y., Tohma, T., Izumikawa, Y., Uehara, H., Ohta, T. Sanfilippo type B syndrome: five patients with an R565P homozygous mutation in the alpha-N-acetylglucosaminidase gene from the Okinawa islands in Japan. J. Hum. Genet. 50: 357-359, 2005.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

82 kDa

Observed Molecular Weight

82 kDa

Gene Name Synonym

N-acetyl-alpha-glucosaminidase

Protein Name

Alpha-N-acetylglucosaminidase

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.