Anti-IL21R Antibody Picoband®

About this product

Boster Bio Anti-IL21R Antibody Picoband® catalog # A00808-1. Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A00808-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21) . It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Synonyms

IL21R; NILR; UNQ3121/PRO10273; Interleukin-21 receptor; IL-21 receptor; IL-21R; Novel interleukin receptor; CD antigen CD360

Gene Name

IL21R

Gene ID

50615

UniProt

Q9HBE5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human IL21R. Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Clonality

Polyclonal

Applications

WB, IHC, Flow Cytometry

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D., Sugamura, K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immun. 167: 1-5, 2001. 2. Barnett, B. E., Ciocca, M. L., Goenka, R., Barnett, L. G., Wu, J., Laufer, T. M., Burkhardt, J. K., Cancro, M. P., Reiner, S. L. Asymmetric B cell division in the germinal center reaction. Science 335: 342-344, 2012. 3. Elsaesser, H., Sauer, K., Brooks, D. G. IL-21 is required to control chronic viral infection. Science 324: 1569-1572, 2009. Note: Erratum: Science 325: 946 only, 2009.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

59 kDa

Observed Molecular Weight

70 kDa

Applications Notes

6

Gene Name Synonym

Interleukin 21 receptor

Protein Name

Interleukin-21 receptor

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.