Anti-Granzyme M/GZMM Antibody

About this product

Boster Bio Anti-Granzyme M/GZMM Antibody catalog # A08286-2. Tested in IHC applications. This antibody reacts with Human.

Specifications

Catalog number

A08286-2-carrier-free

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

GZMM; MET1; Granzyme M; EC 3.4.21.-; Met-1 serine protease; Hu-Met-1; Met-ase; Natural killer cell granular protease

Gene Name

GZMM

Gene ID

3004

UniProt

P51124

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme M/GZMM. Human Granzyme M/GZMM shares 85.7% amino acid (aa) sequence identity with rat Granzyme M/GZMM.

Clonality

Polyclonal

Applications

IHC

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Pao, L. I., Sumaria, N., Kelly, J. M., van Dommelen, S., Cretney, E., Wallace, M. E., Anthony, D. A., Uldrich, A. P., Godfrey, D. I., Papadimitriou, J. M., Mullbacher, A., Degli-Esposti, M. A., Smyth, M. J. Functional analysis of granzyme M and its role in immunity to infection. J. Immun. 175: 3235-3243, 2005. 2. Pilat, D., Fink, T., Obermaier-Skrobanek, B., Zimmer, M., Wekerle, H., Lichter, P., Jenne, D. E. The human Met-ase gene (GZMM) : structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. Genomics 24: 445-450, 1994.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Gene Name Synonym

Granzyme M

Protein Name

Granzyme M

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.