- Catalog number
- MA1010
- Size / count
- 100 µg/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. Three calmodulin genes (CALM1, CALM2, and CALM3) map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively.
- Synonyms
- Calmodulin; CaM; Calm1; Calm, Cam, Cam1; Calm2; Cam2, Camb; Calm3; Cam3, Camc
- Gene Name
- CALM1; CALM2; CALM3
- Gene ID
- Human (801), Mouse (12313), Rat (24242), Human (805), Mouse (12314), Rat (12315), Human (808), Mouse (12315), Rat (50663)
- UniProt
- P62161
- Host
- Mouse
- Reactivity
- Chicken, Rat
- Cross Reactivity
- No cross-reactivity with other proteins
- Immunogen
- Preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.
- Clonality
- Monoclonal
- Clone
- Clone: 6D4
- Tissue Specificity
- High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low- molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
- Applications
- WB
- Field of Research
- Apoptosis, Atherosclerosis, Calcium Signaling, Calmodulin Pathway, Cancer, Cancer Metabolism, Carbohydrate Metabolism, Cardiovascular, Heart Disease, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Signal Transduction, Signaling Pathway
- Purification
- Ascites
- Concentration
- Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
- Function
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca (2+) . Among the enzymes to be stimulated by the calmodulin-Ca (2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity) . .
- References & Citations
- 1. Berchtold, M. W.; Egli, R.; Rhyner, J. A.; Hameister, H.; Strehler, E. E. : Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. Genomics 16: 461-465, 1993.
- Storage Conditions
- Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight
- 16838 MW
- Observed Molecular Weight
- 61 kDa
- Specificity
- No cross reactivity with other proteins.
- Gene Name Synonym
- Calmodulin
- Subcellular Location
- Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. .
- Sequence Similarities
- Belongs to the calmodulin family.
- Protein Name
- Calmodulin
- Isotype
- Mouse IgG1
- Contents
- Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
