Anti-Cathepsin D Ctsd Monoclonal Antibody

About this product

Boster Bio Anti-Cathepsin D Ctsd Monoclonal Antibody catalog # MA1013. Tested in IHC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

MA1013

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Cathepsin D is mapped to chromosome 11. The amino acid sequence predicted from the cDNA sequence shows that human cathepsin D consists of 412 amino acids with 20 and 44 amino acids in a pre- and a prosegment, respectively.

Synonyms

Cathepsin D;3.4.23.5; Cathepsin D 12 kDa light chain; Cathepsin D 9 kDa light chain; Cathepsin D 34 kDa heavy chain; Cathepsin D 30 kDa heavy chain; Ctsd

Gene Name

CTSD

Gene ID

Human (1509), Mouse (13033), Rat (171293)

UniProt

P24268

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Human liver cathepsin D.

Clonality

Monoclonal

Clone

Clone: CTD-19

Tissue Specificity

CTSD: Expressed in the aorta extrcellular space (atprotein level) .

Applications

IHC, WB

Field of Research

Cancer, Cell Adhesion Proteins, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Membrane Proteins, Neuroscience, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Acid protease active in intracellular protein breakdown.

References & Citations

1. Hasilik, A.; von Figura, K.; Grzeschik, K.-H. : Assignment of a gene for human cathepsin D to chromosome 11. (Abstract) Cytogenet. Cell Genet. 32: 284 only, 1982. 2. Qin, S.; Nakai, H.; Byers, M. G.; Eddy, R. L.; Haley, L. L.; Henry, W. M.; Wang, X.; Watkins, P. C.; Chirgwin, J. M.; Shows, T. B. : Mapping FSHB, CAT, and CTSD to specific sites on 11p. (Abstract) Cytogenet. Cell Genet. 46: 678 only, 1987. 3. Faust, P. L.; Kornfeld, S.; Chirgwin, J. M. : Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Nat. Acad. Sci. 82: 4910-4914, 1985.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

44681 MW

Observed Molecular Weight

28 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Cathepsin D

Subcellular Location

Lysosome. Melanosome . Secreted, extracellular space .

Sequence Similarities

Belongs to the peptidase A1 family.

Protein Name

Cathepsin D

Isotype

Mouse IgG2a

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.