Anti-Cyclin A Ccna2 Antibody (Monoclonal, CY-A1)

About this product

Boster Bio Anti-Cyclin A Ccna2 Antibody (Monoclonal, CY-A1) catalog # MA1032. Tested in ICC, WB applications. This antibody reacts with Bovine, Human, Mouse.

Specifications

Catalog number

MA1032

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The mammalian A-type cyclin family consists of 2 members, cyclin A1 (CCNA1) and cyclin A2 (CCNA2) . Human cyclin A gene is assigned to 4q26-q27. Cyclin A protein is synthesized and localized into the nucleus at the onset of S phase in nontransformed mammalian fibroblasts.

Synonyms

Cyclin-A2; Cyclin-A; Ccna2; Ccna, Cyca

Gene Name

CCNA2

Gene ID

Human (890), Mouse (12428), Rat (114494)

UniProt

P51943

Host

Mouse

Reactivity

Bovine, Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Recombinant bovine cyclin A.

Clonality

Monoclonal

Clone

Clone: CY-A1

Tissue Specificity

Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells.

Applications

ICC, WB

Field of Research

Cancer, Cardiovascular, Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Lipids/Lipoproteins

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. .

References & Citations

1. Blanquet, V.; Wang, J.; Chenivesse, X.; Henglein, B.; Garreau, F.; Brechot, C.; Turleau, C. : Assignment of a human cyclin A gene to 4q26-q27. Genomics 8: 595-597, 1990. 2. Girard, F.; Strausfeld, U.; Fernandez, A.; Lamb, N. J. C. : Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67: 1169-1179, 1991.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

47269 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Cyclin-A2

Subcellular Location

Nucleus. Cytoplasm. Cytoplasmic when associated with SCAPER. .

Sequence Similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Protein Name

Cyclin-A2

Isotype

Mouse IgG2a

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.