Anti-Elastin ELN Antibody (Monoclonal, BA-4)

About this product

Boster Bio Anti-Elastin ELN Antibody (Monoclonal, BA-4) catalog # MA1038. Tested in IHC applications. This antibody reacts with Bovine, Human.

Specifications

Catalog number

MA1038

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Elastin is a major structural protein of tissues such as aorta, which must expand rapidly and recover completely. Elastin chains are cross-linked together into an extensible 3D network. It is a molecular determinant of late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in elastin are a cause of autosomal dominant cutis laxa.

Synonyms

Elastin; Tropoelastin; ELN

Gene Name

ELN

Gene ID

Human (2006), Mouse (13717), Rat (25043)

UniProt

P15502

Host

Mouse

Reactivity

Bovine, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Bovine alpha-elastin.

Clonality

Monoclonal

Clone

Clone: BA-4

Tissue Specificity

Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level) . Also expressed in the large arteries, lung and skin. .

Applications

IHC

Field of Research

Cardiovascular, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction, Vasculature

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity) . .

References & Citations

1. Rosenbloom, J. : Personal Communication. Philadelphia, Pa., 4/1984 2. Urban, Z.; Riazi, S.; Seidl, T. L.; Katahira, J.; Smoot, L. B.; Chitayat, D.; Boyd, C. D.; Hinek, A. : Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. Am. J. Hum. Genet. 71: 30-44, 2002. 3. Uitto, J.; Christiano, A. M.; Kahari, V.-M.; Bashir, M. M.; Rosenbloom, J. : Molecular biology and pathology of human elastin. Biochem. Soc. Trans. 19: 824-829, 1991.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

68469 MW

Observed Molecular Weight

426 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Elastin

Subcellular Location

Secreted, extracellular space, extracellular matrix . Extracellular matrix of elastic fibers. .

Sequence Similarities

Belongs to the elastin family.

Protein Name

Elastin

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.