Anti-Myoglobin Mb Antibody (Monoclonal, MG-1)

About this product

Boster Bio Anti-Myoglobin Mb Antibody (Monoclonal, MG-1) catalog # MA1062. Tested in IHC applications. This antibody reacts with Human.

Specifications

Catalog number

MA1062

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Human myoglobin has 152 residues. Two myoglobin variants were found. The myoglobin locus mapped to 22q11-22q13. The myoglobin gene is about 10.5 kb long and contains two introns as in the case with hemoglobin genes. Myoglobin may serve a variety of functions in muscular oxygen supply, such as O (2) storage, facilitated O (2) diffusion, and myoglobin-mediated oxidative phosphorylation.

Synonyms

Myoglobin; Mb

Gene Name

MB

Gene ID

Human (4151), Mouse (17189), Rat (59108)

UniProt

Q9QZ76

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Purified human skeletal muscle myoglobin.

Clonality

Monoclonal

Clone

Clone: MG-1

Tissue Specificity

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. .

Applications

IHC

Field of Research

Cancer, Cardiovascular, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

References & Citations

1. Akaboshi, E. : Cloning of the human myoglobin gene. Gene 33: 241-249, 1985. 2. Jeffreys, A. J.; Wilson, V.; Blanchetot, A.; Weller, P.; Geurts van Kessel, A.; Spurr, N.; Solomon, E.; Goodfellow, P. : The human myoglobin gene: a third dispersed globin locus in the human genome. Nucleic Acids Res. 12: 3235-3243, 1984. 3. Godecke, A.; Flogel, U.; Zanger, K.; Ding, Z.; Hirchenhain, J.; Decking, U. K. M.; Schrader, J. : Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc. Nat. Acad. Sci. 96: 10495-10500, 1999.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

17157 MW

Observed Molecular Weight

200 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Myoglobin

Subcellular Location

Secreted .

Sequence Similarities

Belongs to the globin family.

Protein Name

Myoglobin

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.