- Catalog number
- MA1079
- Size / count
- 100 µg/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma.
- Synonyms
- Cadherin 3, type 1, P-cadherin (Placental) ; Protein Cdh3 ; Cdh3 ; rCG_51631
- Gene Name
- CDH1; CDH2; CDH3
- Gene ID
- Human (999), Mouse (12550), Rat (83502), Human (1000), Mouse (12558), Rat (83501), Human (1001), Mouse (12560), Rat (116777)
- UniProt
- F1LMI3
- Host
- Mouse
- Reactivity
- Chicken, Human, Mouse, Rabbit, Rat, Snake
- Cross Reactivity
- No cross-reactivity with other proteins
- Immunogen
- Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH.
- Clonality
- Monoclonal
- Clone
- Clone: CH-19
- Tissue Specificity
- CDH1: Non-neural epithelial tissues.
- Applications
- IHC, WB
- Field of Research
- Cadherins, Cell Adhesion, Cytoskeleton/ECM, Neuroscience, Sensory System, Signal Transduction, Visual System
- Purification
- Ascites
- Concentration
- Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
- Form
- Lyophilized
- Reconstitution
- Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
- Function
- Cadherins are calcium-dependent cell adhesion proteins. .
- References & Citations
- 1. Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002. 2. Chalmers, I. J.; Hofler, H.; Atkinson, M. J. : Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Genomics 57: 160-163, 1999.
- Storage Conditions
- Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight
- 90415 MW
- Observed Molecular Weight
- 53 kDa
- Specificity
- No cross reactivity with other proteins.
- Gene Name Synonym
- Cadherin 1, type 1, E-cadherin (epithelial) ; cadherin 2, type 1, N-cadherin (neuronal) ; cadherin 3, type 1, P-cadherin (placental)
- Subcellular Location
- CDH1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome. Golgi apparatus, trans-Golginetwork. Note: Colocalizes with DLGAP5 at sites of cell-cellcontact in intestinal epithelial cells. Anchored to actinmicrofilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calciuminflux, results in translocation from sites of cell-cell contactto the cytoplasm. Colocalizes with RAB11A endosomes during itstransport from the Golgi apparatus to the plasma membrane.|Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus, trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity) . |Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus, trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity) . |CDH2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane; Single-pass type I membraneprotein.|Cdh2: Cell membrane |CDH3: Cell membrane; Single-pass type I membraneprotein.|Cdh3: Cell membrane; Single-pass type I membraneprotein.
- Sequence Similarities
- Contains 5 cadherin domains.
- Protein Name
- Cadherin-1; Cadherin-2; Cadherin-3
- Isotype
- Mouse IgG1
- Contents
- Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
