Anti-Tenascin TNN Antibody (Monoclonal, BC-24)

About this product

Boster Bio Anti-Tenascin TNN Antibody (Monoclonal, BC-24) catalog # MA1094. Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Specifications

Catalog number

MA1094

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The tenascins are a family of extracellular matrix proteins (ECMs) . Tenascin is an extracellular matrix protein. It expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena. Human hexabrachion gene (tenascin) is mapped to chromosome 9, bands q32-q34. The coding region of the hexabrachion gene spans approximately 80 kilobases of DNA and consists of 27 exons separated by 26 introns.

Synonyms

Protein Tnn ; Tnn

Gene Name

TNN

Gene ID

Human (63923), Mouse (329278), Rat (304913)

UniProt

Q9UQP3

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Human tenascin.

Clonality

Monoclonal

Clone

Clone: BC-24

Tissue Specificity

Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited areas of the CNS.

Applications

IHC, ICC, WB

Field of Research

Actin, etc., Cardiovascular, Contractility, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

TNN: Involved in neurite outgrowth and cell migration inhippocampal explants.

References & Citations

1. Saga, Y.; Yagi, T.; Ikawa, Y.; Sakakura, T.; Aizawa, S. : Mice develop normally without tenascin. Genes Dev. 6: 1821-1831, 1992. 2. Gulcher, J. R.; Alexakos, M. J.; Le Beau, M. M.; Lemons, R. S.; Stefansson, K. :Chromosomal localization of the human hexabrachion (tenascin) gene and evidence for recent reduplication within the gene. Genomics 6: 616-622, 1990. 3. Gulcher, J. R.; Nies, D. E.; Alexakos, M. J.; Ravikant, N. A.; Sturgill, M. E.; Marton, L. S.; Stefansson, K. : Structure of the human hexabrachion (tenascin) gene. Proc. Nat. Acad. Sci. 88: 9438-9442, 1991.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

173250 MW

Observed Molecular Weight

272 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tenascin N

Subcellular Location

TNN: Secreted, extracellular space, extracellularmatrix.|Tnn: Secreted, extracellular space, extracellularmatrix.

Sequence Similarities

Belongs to the tenascin family.

Protein Name

Tenascin-N

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.