Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16)

About this product

Boster Bio Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16) catalog # MA1100. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.

Specifications

Catalog number

MA1100

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.

Synonyms

Tyrosine 3-monooxygenase;1.14.16.2; Tyrosine 3-hydroxylase; TH; Th

Gene Name

TH

Gene ID

Human (7054), Mouse (21823), Rat (25085)

UniProt

P04177

Host

Mouse

Reactivity

Human, Mouse, Rabbit, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

Rat tyrosine hydroxylase (TH) .

Clonality

Monoclonal

Clone

Clone: TH-16

Tissue Specificity

TH: Mainly expressed in the brain and adrenalglands.

Applications

IHC, WB

Field of Research

Cancer, Cancer Metabolism, Cell Type Marker, Endocrine Metabolism, Hormone Biosynthesis, Hypoxia, Metabolic Signaling Pathway, Metabolism, Metabolism Processes, Neuron Marker, Neuroscience, Neurotransmitter, Pathways and Processes, Response To Hypoxia

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Plays an important role in the physiology of adrenergic neurons.

References & Citations

1. Brilliant, M. H.; Niemann, M. M.; Eicher, E. M. : urine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man. J. Neurogenet. 4: 259-266, 1987. 2. Craig, S. P.; Buckle, V. J.; Craig, I. W.; Lamouroux, A.; Mallet, J. : Localization of the human tyrosine hydroxylase gene to chromosome 11p15. (Abstract) Cytogenet. Cell Genet. 40: 610 only, 1985. 3. Craig, S. P.; Buckle, V. J.; Lamouroux, A.; Mallet, J.; Craig, I. : Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Cytogenet. Cell Genet. 42: 29-32, 1986.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

55966 MW

Observed Molecular Weight

59 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tyrosine 3-monooxygenase

Subcellular Location

Cytoplasm, cytoskeleton.

Sequence Similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Protein Name

Tyrosine 3-monooxygenase

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.