Anti-Beta-HCG CGB Antibody (Monoclonal, PC-2)

About this product

Boster Bio Anti-Beta-HCG CGB Antibody (Monoclonal, PC-2) catalog # MA1111. Tested in IHC applications. This antibody reacts with Human.

Specifications

Catalog number

MA1111

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Beta-HCG (beta-Human Chorionic Gonadotropin), also termed as Chorionic Gonadotropin, Beta Chain (CGB) . It is encoded by a multigene cluster composed of six homologous sequences. And in the family of beta-containing glycoprotein hormones, beta-HCG is unique in that it contains an extension of 29 amino acids at its COOH end. beta-HCG is mapped to 19q13.32 and expressed in trophoblast and various malignant tumors promotes cellular motility in vivo. beta-HCG has a novel function in uterine adaptation to early pregnancy as well as in tumor development and underline the importance of HCG as an as yet unrecognized angiogenic factor.

Synonyms

Choriogonadotropin subunit beta; CG-beta; Chorionic gonadotrophin chain beta; CGB; CGB3; CGB5; CGB7; CGB8

Gene Name

CGB

Gene ID

Human (1082)

UniProt

P01233

Host

Mouse

Reactivity

Human

Cross Reactivity

Cross-reactivities with LH, FSH and TSH are less than 0.3%.

Immunogen

Purified human Chorionic Gonadotropin.

Clonality

Monoclonal

Clone

Clone: PC-2

Tissue Specificity

Placenta.

Applications

IHC

Field of Research

Chromatin Remodeling, Co-Factors, Epigenetics and Nuclear Signaling, Transcription

Purification

Ascites

Concentration

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Form

Lyophilized

Reconstitution

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Function

Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

References & Citations

1. Bo, M.; Boime, I. : Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. J. Biol. Chem. 267: 3179-3184, 1992.) 2. Policastro, P.; Ovitt, C. E.; Hoshina, M.; Fukuoka, H.; Boothby, M. R.; Biome, I. : The beta-subunit of human chorionic gonadotropin is encoded by multiple genes. J. Biol. Chem. 258: 11492-11499, 1983. 3. Zygmunt, M.; Herr, F.; Keller-Schoenwetter, S.; Kunzi-Rapp, K.; Munstedt, K.; Rao, C. V.; Lang, U.; Preissner, K. T. : Characterization of human chorionic gonadotropin as a novel angiogenic factor. J. Clin. Endocr. Metab. 87: 5290-5296, 2002.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

17739 MW

Observed Molecular Weight

55 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Choriogonadotropin subunit beta

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the glycoprotein hormones subunit beta family.

Protein Name

Choriogonadotropin subunit beta

Isotype

Mouse IgG1

Contents

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.