Anti-C Reactive Protein/CRP Antibody Picoband®

About this product

Boster Bio Anti-C Reactive Protein/CRP Antibody catalog # PA1028. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1028

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

C Reactive Protein (CRP) is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is composed of 5 identical, 21,500-molecular weight subunits. CRP mediates activities associated with preimmune nonspecific host resistance. CRP shows the strongest association with cardiovascular events. It is detectable on the surface of about 4% of normal peripheral blood lymphocytes. Acute phase reactant CRP is produced in the liver.

Synonyms

C-reactive protein; C-reactive protein (1-205) ; CRP; PTX1

Gene Name

CRP

Gene ID

1401

UniProt

P02741

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human C Reactive Protein.

Clonality

Polyclonal

Tissue Specificity

Found in plasma.

Applications

WB

Field of Research

Apoptosis, Atherosclerosis, Cardiovascular, Chromatin Binding Proteins, Complement, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Macrophage/Inflammation, Metabolism, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

References & Citations

1. Kilpatrick, J. M.; Volanakis, J. E. : Molecular genetics, structure, and function of C-reactive protein. Immun. Res. 10: 43-53, 1991. 2. Kuta, A. E.; Baum, L. L. : C-reactive protein is produced by a small number of normal human peripheral blood lymphocytes. J. Exp. Med. 164: 321-326, 1986. 3. Oliveira, E. B.; Gotshlich, E. C.; Liu, T. : Primary structure of human C-reactive protein. J. Biol. Chem. 254: 489-502, 1979.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

25039 MW

Observed Molecular Weight

43 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-reactive protein

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the pentaxin family.

Protein Name

C-reactive protein

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.