Anti-SFTPA1 Antibody Picoband®

About this product

Boster Bio Anti-SFTPA1 Antibody catalog # PA1347. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1347

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Surfactant protein A is an innate immune system collectin. The gene encoding SP-A map to mouse chromosome 14.1. Surfactant protein-A, which plays a role in innate host defense in the lung, is also expressed in the Eustachian tube. We report that the frequency of specific surfactant protein-A haplotypes and genotypes differs between children with recurrent otitis media compared with a control population.

Synonyms

Pulmonary surfactant-associated protein A1; PSP-A; PSPA; SP-A; SP-A1;35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4; SFTPA1; COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B

Gene Name

SFTPA1

Gene ID

653509

UniProt

Q8IWL2

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SFTPA1, different from the rat sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in neurons of the rolandic area of the brain (at protein level) . Expressed in the brain.

Applications

WB

Field of Research

Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

References & Citations

1. Moore, K. J., D'Amore-Bruno, M. A., Korfhagen, T. R., Glasser, S. W., Whitsett, J. A., Jenkins, N. A., Copeland, N. G. Chromosomal localization of three pulmonary surfactant protein genes in the mouse. Genomics 12: 388-393, 1992. 2. Ramet, M., Lofgren, J., Albo, O.-P., Hallman, M. Surfactant protein-A gene locus associated with recurrent otitis media. J. Pediat. 138: 266-268, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

26242 MW

Observed Molecular Weight

26-35 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Pulmonary surfactant-associated protein A1

Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Sequence Similarities

Belongs to the SFTPA family.

Protein Name

Pulmonary surfactant-associated protein A1 (PSP-A/PSPA/SP-A/SP-A1)

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.