Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband®

About this product

Boster Bio Anti-C-C chemokine receptor type 4 CCR4 Antibody catalog # PA1517. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1517

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CCR4, C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194) . The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Synonyms

C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; CD194; Ccr4; Cmkbr4

Gene Name

CCR4

Gene ID

12773

UniProt

P51680

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse CCR4, identical to the related rat sequence.

Clonality

Polyclonal

Tissue Specificity

Expressed in the thymus, macrophages and T- and B-cells.

Applications

WB

Field of Research

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Vascular Inflammation

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS) -induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. .

References & Citations

1. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O.The T cell-ed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.J. Biol. Chem. 272: 15036-15042, 1997. 2. Imai, T., Chantry, D., Raport, C. J., Woods, C. L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W.Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.J. Biol. Chem. 273: 1764-1768, 1998. 3. Oo, Y. H., Weston, C. J., Lalor, P. F., Curbishley, S. M., Withers, D. R., Reynolds, G. M., Shetty, S., Harki, J., Shaw, J. C., Eksteen, B., Hubscher, S. G., Walker, L. S. K., Adams, D. H.Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.J. Immun. 184: 2886-2898, 2010.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

41408 MW

Observed Molecular Weight

41 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-C chemokine receptor type 4

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Protein Name

C-C chemokine receptor type 4 (C-C CKR-4/CC-CKR-4/CCR-4/CCR4)

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.