Anti-hCG receptor/LHCGR Antibody Picoband®

About this product

Boster Bio Anti-hCG receptor/LHCGR Antibody catalog # PA1552. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1552

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The luteinizing hormone/choriogonadotropin receptor is a member of a subfamily of G protein-coupled receptors (GPCR) characterized by the presence of a large N-terminal extracellular domain containing several leucine-rich repeats (LRR) . This glycoprotein hormone receptor family has been named the LRR-containing GPCR (LGR) family. The LHCGR gene contains 11 exons and spans approximately 80 kb and it is mapped to chromosome 2p21. In the ovary, theca, stromal, late-stage (luteinizing) granulosa, and luteal cells contain LHCGR. In the testes, Leydig cells contain LHCRG.

Synonyms

Lutropin-choriogonadotropic hormone receptor; LH/CG-R; Luteinizing hormone receptor; LHR; LSH-R; LHCGR; LCGR, LGR2, LHRHR

Gene Name

LHCGR

Gene ID

3973

UniProt

P22888

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human hCG receptor, different from the relative rat sequence by two amino acids, mouse sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Gonadal and thyroid cells.

Applications

IHC, WB

Field of Research

Endocrine System, G Protein Signaling, More Gpcr, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

References & Citations

1. Ascoli, M., Fanelli, F., Segaloff, D. L.The lutropin/choriogonadotropin receptor, a 2002 perspective.Endocr. Rev. 23: 141-174, 2002. 2. Themmen, A. P. N., Huhtaniemi, I. T.Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.Endocr. Rev. 21: 551-583, 2000.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

78643 MW

Observed Molecular Weight

78 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Lutropin-choriogonadotropic hormone receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.

Protein Name

Lutropin-choriogonadotropic hormone receptor (LH/CG-R)

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.