Anti-Desmoglein 2/DSG2 Antibody Picoband®

About this product

Boster Bio Anti-Desmoglein 2/DSG2 Antibody catalog # PA1559. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1559

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

Synonyms

Desmoglein-2; Cadherin family member 5; HDGC; DSG2; CDHF5

Gene Name

DSG2

Gene ID

1829

UniProt

Q14126

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Desmoglein 2, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

All of the tissues tested and carcinomas.

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Cadherins, Cancer, Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

References & Citations

1. Arnemann J, Spurr NK, Magee AI, Buxton RS (Jul 1992) . The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18. Genomics 13 (2) : 484–6. 2. Entrez Gene: DSG2 desmoglein 2. mutations in DSG2 contribute to the development of ARVD/C. 3. Syrris, P., Ward, D., Asimaki, A., Evans, A., Sen-Chowdhry, S., Hughes, S. E., McKenna, W. J. Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease. Europ. Heart J. 28: 581-588, 2007.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

122294 MW

Observed Molecular Weight

160 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Desmoglein-2

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Sequence Similarities

Contains 4 cadherin domains.

Protein Name

Desmoglein-2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.