Anti-NRG2 Antibody Picoband®

About this product

Boster Bio Anti-NRG2 Antibody catalog # PA1637. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1637

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

Synonyms

Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2; Neuregulin-2; NRG-2; Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases; NTAK; NRG2; NTAK

Gene Name

NRG2

Gene ID

9542

UniProt

O14511

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human NRG2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Restricted to the cerebellum in the adult.

Applications

WB

Field of Research

Intracellular Signaling, Kinases, Neuroscience, Neurotransmission, Protein Phosphorylation, Signal Transduction, Tyrosine Kinases

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

References & Citations

1. Britto, J. M., Lukehurst, S., Weller, R., Fraser, C., Qiu, Y., Hertzog, P., Busfield, S. J. Generation and characterization of neuregulin-2-deficient mice. Molec. Cell. Biol. 24: 8221-8226, 2004. 2. Burden, S., Yarden, Y. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18: 847-855, 1997. 3. Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997) . Ligands for ErbB-family receptors encoded by a neuregulin-like gene.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

91679 MW

Observed Molecular Weight

91 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Pro-neuregulin-2, membrane-bound isoform

Subcellular Location

Pro-neuregulin-2, membrane-bound isoform: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .

Sequence Similarities

Belongs to the neuregulin family.

Protein Name

Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2)

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.