Anti-Lipocalin-1 LCN1 Antibody Picoband®

About this product

Boster Bio Anti-Lipocalin-1 LCN1 Antibody catalog # PA1659. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1659

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lipocalin-1 (LCN1), also known as PREALBUMIN, TEAR or VEGP, is a protein that in humans is encoded by the LCN1 gene. Lipocalin-1 is a member of the lipocalin family of small secretory proteins, which is mapped on 9q34.3. Lipocalin-1 is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. It may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. LCN1 inhibits the cysteine-protease papain in vitro, similar to cystatins. And LCN1 plays a role in the nonimmunologic defense and in the control of inflammatory processes in oral and ocular tissues. The investigations presented the first clear evidence that LCN1 is induced in infection or inflammation and supported the idea that this lipocalin functions as a physiologic protection factor of epithelia in vivo.

Synonyms

Lipocalin-1; Tear lipocalin; Tlc; Tear prealbumin; TP; Von Ebner gland protein; VEG protein; LCN1; VEGP

Gene Name

LCN1

Gene ID

3933

UniProt

P31025

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human LCN1.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.

Applications

IHC, WB

Field of Research

Cell Biology, Neuroscience, Protease Inhibitors, Proteolysis/Ubiquitin, Sensory System

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

References & Citations

1. Baumgartner, M., Holzfeind, P., Redl, B. Assignment of the gene for human tear prealbumin (LCN1), a member of the lipocalin superfamily, to chromosome 8q24. Cytogenet. Cell Genet. 65: 101-103, 1994. 2. Blaker, M., Kock, K., Ahlers, C., Buck, F., Schmale, H. Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands. Biochim. Biophys. Acta 1172: 131-137, 1993. 3. Glasgow BJ, Abduragimov AR, Gasymov OK, Yusifov TN (2003) . Tear lipocalin: structure, function and molecular mechanisms of action. Adv. Exp. Med. Biol. 506 (Pt A) : 555–65.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

19250 MW

Observed Molecular Weight

19 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Lipocalin-1

Subcellular Location

Secreted.

Protein Name

Lipocalin-1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.