Anti-TRPC3 Antibody Picoband®

About this product

Boster Bio Anti-TRPC3 Antibody catalog # PA1753. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1753

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3; TRPC3; TRP3

Gene Name

TRPC3

Gene ID

7222

UniProt

Q13507

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TRPC3, identical to the related rat and mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Applications

IHC, WB

Field of Research

Calcium Channels, Calcium Signaling, Cardiovascular, Hypertrophy, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. .

References & Citations

1. Fusco FR, Martorana A, Giampà C, De March Z, Vacca F, Tozzi A, Longone P, Piccirilli S, Paolucci S, Sancesario G, Mercuri NB, Bernardi G (July 2004) . Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytes. Neuroscience Letters. 365 (2) : 137–42. 2. Li HS, Xu XZ, Montell C (1999) . Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron. 24 (1) : 261–73. 3. Zhou FW, Matta SG, Zhou FM (January 2008) . Constitutively active TRPC3 channels regulate basal ganglia output neurons. The Journal of Neuroscience. 28 (2) : 473–82.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

96009 MW

Observed Molecular Weight

110 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Short transient receptor potential channel 3

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.

Protein Name

Short transient receptor potential channel 3 (TrpC3)

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.