Anti-SDHC Antibody Picoband®

About this product

Boster Bio Anti-SDHC Antibody catalog # PA1839. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA1839

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) also known as SDH3, SUCCINATE DEHYDROGENASE CYTOCHROME b. The  SDHC  gene contains 6 exons. Oostveen et al. (1995)   found that in fact it was protein from the bovine SDH3 gene (encoding 1 of the 2 integral membrane proteins) that complemented the hamster mutation. The authors localized the human SDH3 gene to the short arm of chromosome one, within 1 to 2 Mb from the centromere.  Additionally, the authors stated that Southern analyses of human genomic DNA suggested that there are multiple SDH3 genes or pseudogenes. Elbehti-Green et al. (1998)   confirmed the assignment of the  SDHC  gene to 1q21 by FISH. Baysal et al. (2004)   described a family with PGL3 in which an 8,372-bp deletion in the  SDHC  gene was transmitted both maternally and paternally, without evidence of genomic imprinting.&nbsp

Synonyms

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL; SDHC; CYB560, SDH3

Gene Name

SDHC

Gene ID

6391

UniProt

Q99643

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SDHC, different from the related mouse and rat sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. .

Applications

IHC, WB

Field of Research

Cancer Susceptibility, Cell Biology, Developmental Biology, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Mitochondria, Mitochondrial Metabolism, Organelles, Oxidative Phosphorylation, Oxidative Stress, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers, Transcription, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) .

References & Citations

1. Baysal, B. E., Willett-Brozick, J. E., Filho, P. A. A., Lawrence, E. C., Myers, E. N., Ferrell, R. E. An Alu-mediated partial SDHC deletion causes familial and sporadic paraganglioma. J. Med. Genet. 41: 703-709, 2004. 2. Elbehti-Green, A., Au, H. C., Mascarello, J. T., Ream-Robinson, D., Scheffler, I. E. Characterization of the human SDHC gene encoding one of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria. Gene 213: 133-140, 1998. 3. Oostveen, F. G., Au, H. C., Meijer, P.-J., Scheffler, I. E. A Chinese hamster mutant cell line with a defect in the integral membrane protein C (II-3) of complex II of the mitochondrial electron transport chain. J. Biol. Chem. 270: 26104-26108, 1995.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

18610 MW

Observed Molecular Weight

19 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the cytochrome b560 family.

Protein Name

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.