Anti-Lipoma-preferred partner LPP Antibody Picoband®

About this product

Boster Bio Anti-Lipoma-preferred partner LPP Antibody catalog # PA2040. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2040

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

LPP (Lim Domain-Containing Preferred Translocation Partner in Lipoma) is a protein that in humans is encoded by the LPP gene. Petit et al. (1996) commented that the LPP-encoded protein should be classified as a novel member of the group 3 proteins of the LIM protein gene family. By partial cDNA cloning, Petit et al. (1996) established features of the genetic organization of LPP. The gene was found to span a genomic region of over 400 kb. By FISH and Southern blot analyses, Daheron et al. (2001) identified a rearrangement in the mixed lineage leukemia gene due to a novel t (3;11) (q28; q23) translocation in a patient who developed acute myeloid leukemia of the M5 type 3 years after treatment for a follicular lymphoma.

Synonyms

Lipoma-preferred partner; LIM domain-containing preferred translocation partner in lipoma; LPP

Gene Name

LPP

Gene ID

4026

UniProt

Q93052

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human LPP.

Clonality

Polyclonal

Tissue Specificity

Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes. .

Applications

WB

Field of Research

Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. .

References & Citations

1. Daheron, L., Veinstein, A., Brizard, F., Drabkin, H., Lacotte, L., Guilhot, F., Larsen, C. J., Brizard, A., Roche, J. Human LPP gene is fused to MLL in a secondary acute leukemia with a t (3;11) (q28; q23) . Genes Chromosomes Cancer 31: 382-389, 2001. 2. Petit, M. M. R., Mols, R., Schoenmakers, E. F. P. M., Mandahl, N., Van de Ven, W. J. M. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36: 118-129, 1996.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

65746 MW

Observed Molecular Weight

80 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Lipoma-preferred partner

Subcellular Location

Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.

Sequence Similarities

Belongs to the zyxin/ajuba family.

Protein Name

Lipoma-preferred partner

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.