Anti-Annexin VII/ANXA7 Antibody Picoband®

About this product

Boster Bio Anti-Annexin VII/ANXA7 Antibody catalog # PA2076. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2076

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

ANXA7 (Annexin A7), also known as ANX7 or SNX, is a protein that in humans is encoded by the ANXA7 gene. Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. Shirvan et al. (1994) isolated genomic clones of the ANXA7 gene and assigned the gene to 10q21.1-q21.2 by study of somatic cell hybrids and by in situ hybridization. Srivastava et al. (2001) concluded that the ANX7 gene exhibits many biologic and genetic properties expected of a tumor suppressor gene and may play a role in prostate cancer progression. Caohuy et al. (1996) present experimental evidence, based on studies of recombinant human ANXA7 and isolated bovine chromaffin cells, that ANXA7 is a Ca (2+) -dependent GTP binding protein. ANXA7 was active in a chromaffin granule aggregation assays in the presence of Ca (2+) and GTP, and was deactivated upon GTP hydrolysis.

Synonyms

Annexin A7; Annexin VII; Annexin-7; Synexin; ANXA7; ANX7, SNX; OK/SW-cl.95

Gene Name

ANXA7

Gene ID

310

UniProt

P20073

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Annexin VII, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Calcium Channels, Calcium Signaling, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

References & Citations

1. Caohuy, H., Srivastava, M., Pollard, H. B. Membrane fusion protein synexin (annexin VII) as a Ca (2+) /GTP sensor in exocytotic secretion. Proc. Nat. Acad. Sci. 93: 10797-10802, 1996. 2. Shirvan, A., Srivastava, M., Wang, M. G., Cultraro, C., Magendzo, K., McBride, O. W., Pollard, H. B., Burns, A. L. Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. Biochemistry 33: 6888-6901, 1994. 3. Srivastava, M., Bubendorf, L., Srikantan, V., Fossom, L., Nolan, L., Glasman, M., Leighton, X., Fehrle, W., Pittaluga, S., Raffeld, M., Koivisto, P., Willi, N., Gasser, T. C., Kononen, J., Sauter, G., Kallioniemi, O. P., Srivastava, S., Pollard, H. B. ANX7, a candidate tumor suppressor gene for prostate cancer. Proc. Nat. Acad. Sci. 98: 4575-4580, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

52739 MW

Observed Molecular Weight

50 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Annexin A7

Subcellular Location

Secreted .

Sequence Similarities

Belongs to the annexin family.

Protein Name

Annexin A7

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.