Anti-PMP70/ABCD3 Antibody Picoband®

About this product

Boster Bio Anti-PMP70/ABCD3 Antibody catalog # PA2091. Tested in ICC/IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2091

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene was assigned to human chromosome 1p21-p22 by in situ hybridization. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders.

Synonyms

ATP-binding cassette sub-family D member 3;70 kDa peroxisomal membrane protein; PMP70; ABCD3; PMP70, PXMP1

Gene Name

ABCD3

Gene ID

5825

UniProt

P28288

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PMP70, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Applications

ICC/IF, IHC, WB

Field of Research

Alzheimer's Disease, Cancer, Lipid Metabolism, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelle Proteins, Organelles, Protein Trafficking, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382) . The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity (PubMed:11248239) . .

References & Citations

1. Gartner J, Moser H, Valle D (June 1993) . Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome.Nat Genet 1 (1) : 16–23. 2. Gartner J, Kearns W, Rosenberg C, Pearson P, Copeland NG, Gilbert DJ, Jenkins NA, Valle D (April 1993) . Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3. Genomics 15 (2) : 412–4. 3. Entrez Gene: ABCD3 ATP-binding cassette, sub-family D (ALD), member 3.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

75 kDa

Observed Molecular Weight

70 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

ATP-binding cassette sub-family D member 3

Subcellular Location

Peroxisome membrane ; Multi-pass membrane protein .

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein Name

ATP-binding cassette sub-family D member 3

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.