Anti-Protein Wnt-3a Wnt3a Antibody Picoband®

About this product

Boster Bio Anti-Protein Wnt-3a Wnt3a Antibody catalog # PA2120. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2120

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Wingless-type MMIV integration site family, member 3A is a protein that in humans is encoded by the WNT3A gene. This gene is a member of the WNT gene family. The gene was assigned to human chromosome 1q42.13. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product.

Synonyms

Protein Wnt-3a; WNT3A

Gene Name

WNT3A

Gene ID

89780

UniProt

P56704

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Wnt3a, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

Applications

WB

Field of Research

Developmental Biology, Embryogenesis, Neurogenesis, Neurology Process, Neuroscience, Secreted, Signaling Pathways, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.

References & Citations

1. Aulehla, A., Herrmann, B. G. Segmentation in vertebrates: clock and gradient finally joined. Genes Dev. 18: 2060-2067, 2004. 2. Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., Rando, T. A. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317: 807-810, 2007. 3. Saitoh T, Hirai M, Katoh M (Jun 2001) . Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region. Biochem Biophys Res Commun 284 (5) : 1168–75.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39365 MW

Observed Molecular Weight

39 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Protein Wnt-3a

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Sequence Similarities

Belongs to the Wnt family.

Protein Name

Protein Wnt-3a

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.