Anti-C-C chemokine receptor type 9 CCR9 Antibody Picoband®

About this product

Boster Bio Anti-C-C chemokine receptor type 9 CCR9 Antibody catalog # PA2122. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2122

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

C-C chemokine receptor type 9, also called GPR-9-6 or CDw199, is a protein that in humans is encoded by the CCR9 gene. The protein encoded by this gene is a member of the beta chemoking receptor family. By radiation hybrid analysis and organization of BAC contigs by FISH on combed genomic DNA, the CCR9 gene within the CCR cluster was localized at 3p21.3. It is the receptor for chemokine SCYA25/TECK. This gene subsequently transduces a signal by increasing the intracellular calcium ions level. It is an alternative coreceptor with CD4 for HIV-1 infection. This gene may play a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract.

Synonyms

C-C chemokine receptor type 9; C-C CKR-9; CC-CKR-9; CCR-9; G-protein coupled receptor 28; GPR-9-6; CDw199; CCR9; GPR28

Gene Name

CCR9

Gene ID

10803

UniProt

P51686

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human CCR9.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in the thymus and low in lymph nodes and spleen. .

Applications

WB

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

References & Citations

1. Eksteen, B., Grant, A. J., Miles, A., Curbishley, S. M., Lalor, P. F., Hubscher, S. G., Briskin, M., Salmon, M., Adams, D. H. Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J. Exp. Med. 200: 1511-1517, 2004. 2. Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M., von Andrian, U. H. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424: 88-93, 2003. 3. Papadakis, K. A., Prehn, J., Nelson, V., Cheng, L., Binder, S. W., Ponath, P. D., Andrew, D. P., Targan, S. R. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J. Immun. 165: 5069-5076, 2000. 4. Wendland, M., Czeloth, N., Mach, N., Malissen, B., Kremmer, E., Pabst, O., Forster, R. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc. Nat. Acad. Sci. 104: 6347-6352, 2007.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

42016 MW

Observed Molecular Weight

42 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

C-C chemokine receptor type 9

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Protein Name

C-C chemokine receptor type 9

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.