Anti-P2X6/P2RX6 Antibody Picoband®

About this product

Boster Bio Anti-P2X6/P2RX6 Antibody catalog # PA2128. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2128

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Purinergic receptor P2X-Like 1, also known as P2X6, is a protein that in humans is encoded by the P2RX6 gene. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. This gene belongs to the family of P2X receptors. P2RXL1 gene was mapped to chromosome 22q11 by fluorescence in situ hybridization. This gene is a receptor for ATP that acts as a ligand-gated ion channel. It can mediate rapid and selective permeability to cations.

Synonyms

P2X purinoceptor 6; P2X6; ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1; P2RX6; P2RXL1, P2X6

Gene Name

P2RX6

Gene ID

9127

UniProt

O15547

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human P2X6.

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in skeletal muscle.

Applications

WB

Field of Research

Cancer, Cardiovascular, Ligand-Gated Ion Channels, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Receptors / Channels, Signal Transduction, Vasculature

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for ATP that acts as a ligand-gated ion channel. .

References & Citations

1. Collo, G., North, R. A., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A., Buell, G. Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16: 2495-2507, 1996. 2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999) . The DNA sequence of human chromosome 22.Nature 402 (6761) : 489–95. 3. Urano, T., Nishimori, H., Han, H., Furuhata, T., Kimura, Y., Nakamura, Y., Tokino, T.Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res. 57: 3281-3287, 1997.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48829 MW

Observed Molecular Weight

39 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

P2X purinoceptor 6

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the P2X receptor family.

Protein Name

P2X purinoceptor 6

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.