Anti-Collagen I/COL1A1 Antibody Picoband®

About this product

Boster Bio Anti-Collagen I/COL1A1 Antibody catalog # PA2140-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2140-1

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pro-alpha1 chains of type I collagen

Synonyms

Collagen alpha-1 (I) chain; Alpha-1 type I collagen; COL1A1

Gene Name

COL1A1

Gene ID

1277

UniProt

P02452

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen I, different from the related rat and mouse sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Applications

IHC, WB

Field of Research

Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen) .

References & Citations

1. Aihara, M., Lindsey, J. D., Weinreb, R. N. Ocular hypertension in mice with a targeted type I collagen mutation. Invest. Ophthal. Vis. Sci. 44: 1581-1585, 2003. 2. Cabral, W. A., Makareeva, E., Colige, A., Letocha, A. D., Ty, J. M., Yeowell, H. N., Pals, G., Leikin, S., Marini, J. C. Mutations near amino end of alpha-1 (I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. J. Biol. Chem. 280: 19259-19269, 2005.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

138941 MW

Observed Molecular Weight

180-200 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Collagen alpha-1 (I) chain

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Belongs to the fibrillar collagen family.

Protein Name

Collagen alpha-1 (I) chain

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.