Anti-Sodium/hydrogen exchanger 2 SLC9A2 Antibody Picoband®

About this product

Boster Bio Anti-Sodium/hydrogen exchanger 2 SLC9A2 Antibody catalog # PA2219. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2219

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sodium– hydrogen exchanger 2, also called SLC9A2 or NHE2 is a protein that in humans is encoded by the SLC9A2 gene. This gene is mapped to 2q12.1. The Na+/H+ exchangers (NHE) are membrane proteins involved in cell volume. The exchanger (which they called NHE2) is found in several tissues, including intestine and kidney, and is highly expressed in villus and distal convoluted tubules. This gene is involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. It seems to play an important role in colonic sodium absorption.

Synonyms

Sodium/hydrogen exchanger 2; Na (+) /H (+) exchanger 2; NHE-2; Solute carrier family 9 member 2; SLC9A2; NHE2

Gene Name

SLC9A2

Gene ID

6549

UniProt

Q9UBY0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC9A2, different from the related rat and mouse sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.

Applications

IHC, WB

Field of Research

Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis/Ubiquitin

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

References & Citations

1. Ghishan, F. K., Knobel, S. M., Summar, M. Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2) . Genomics 30: 25-30, 1995. 2. Pathak, B. G., Shull, G. E., Jenkins, N. A., Copeland, N. G. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics 31: 261-263, 1996.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

91520 MW

Observed Molecular Weight

91 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Sodium/hydrogen exchanger 2

Subcellular Location

Membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein Name

Sodium/hydrogen exchanger 2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.